What is the difference between Viagra (sildenafil), Cialis (tadalafil), and Levitra (vardenafil)? 

The newest medication is called Stendra (avanafil). It works in 15 minutes! 

It has been reported that 50% of men between 40 and 70, have some form of erectile dysfunction.  Also called ED meds, many men will try these medications, feeling great success. 

How do erectile disfunction medicines work?:

They boost a chemical in the body called nitric oxide and block chemicals called PDE5 enzymes. The chemical cause certain muscles in the body to relax so blood flows better (freely), into the p*nis, allowing a stronger and harder erection, lasting longer during sex.

CIALIS (generic brand vardenafil):

Cialis is also helpful and is medically approved to treat enlarged prostates named benign prostatic hypertrophy (BPH). Vardenafil (Cialis), lasts much longer than sildenafil (Viagra). Many men believe this medication prolongs the duration of their erections for up to 36 hours, but it can be taken up to 30 minutes before sexual activity (intercourse).

Cialis can be prescribed in much lower dosage. Taken daily, Cialis may also help with prostate issues

LEVITRA (vardenafil):

You must take the pill at least an hour prior to intercourse to be effective and may have less negative effects compared to Cialis or Viagra.

VIAGRA (sildenafil):

Viagra is the first and most popular of these erection enhancing medications but may cause muscle aches and rashes. May be taken 30 minutes prior to anticipated intercourse (s*x).  Purchasing a 100 mg tablet saves money by starting with ½ tablet. (50mg is the recommended starting dose). If you’ve never tried any Erectile Dysfunction (ED) medication, starting with sildenafil, may be wise, as any negative effects including dizziness, will last only 6 hrs. 

STENDRA (avanafil):

This is the newest ED drug.  Be hard in 15 minutes! (But not yet available as a generic, so much more costly).  


  • When used as prescribed, these medications are generally very effective. Take them exactly as it is prescribed. 
  • Stendra, (avanafil), has the fewest side effects and may work in 15 minutes.
  • Viagra, (sildenafil), although the most well-known, has the most side effects
  • Do not drink an excessive amount of alcohol while taking these medications.
  • Be extremely careful (discuss first with doctor or clinician), when medications for heart conditions such as hypertension (high blood pressure), or angina.




Warning about Erectile Dysfunction Medication!

  • Be very careful (discuss first with your doctor or clinician), if taking medications for prostate issues. 
  • Having difficulty getting or keeping an erection may be a symptom of systemic illness such as diabetes, of very high cholesterol. See your doctor / health care provider if persistent symptoms last more than 1 month. 
  • If you have an erection that lasts longer than 4 hours, seek emergency care. 
  • Unless prescribed by a doctor/clinician, online purchased erectile dysfunction medications are NOT FDA-approved. They may contain ineffective or harmful ingredients.
  • DO NOT TAKE an erectile dysfunction pill, if you have taken these medications: *riociguat, *isosorbide dinitrate, *isosorbide mononitrate, *nitroglycerine. 
  • *Combining these medications may cause severe illness or death. 
  • Counterfeit drugs are a growing problem, especially when ordered online. 
  • Up to 67% of men will purchase medication for erectile dysfunction on the internet. 
  • Despite easily purchasing these drugs on the internet, they can interact with other commonly taken prescription medications.
  • Be VERY CAREFUL, speak to a medical provider / doctor if taking medications for the  heart, blood pressure or for the prostate.
  • Up to 70% of prescriptions of Viagra (sildenafil), Levitra (vardenafil), or Cialis (tadalafil) received by mail are counterfeit. (fake)
  • To read more: Google:  “Counterfeit phosphodiesterase type 5 inhibitors pose significant safety risks” by G Jackson. International Journal of Clinical Practice

Albert Luongo, MS, PA, MBA, DMSc

Luongo Medical Care (LMC) 90 Morgan Street #203, Stamford, CT 06905, 203-461-4767

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